The Great War
The Great War is the name given to the war fought by The Big Three.
This war was massive in scale, and was the consequence of the decision to move forward with Substantia Naturae and the effects of the Second Relocation. Vistian and Iratus alike are enraged with humanity, and many other species' side with them in an attempt to wipe humankind off the face of every planet they inhabit.
In their eyes, humans do not deserve to live, as all they serve to do is betray.
The Great War spanned a total of 1,083 years, from 4680 AD to 5763 AD, and at its end, humanity was near extinction.